Medaka arrestin



Arrestin (S-antigen) binds to the phosphorylated rhodopsin, precluding further activation of transducin and so shutting down the photo-transduction cascade. Phylogenetic analysis suggests that arrestins can be classified into three major families: vertebrate visual arrestins, vertebrate b-arrestins and arthropod arrestins. Vertebrate visual arrestins are distinguished as rod or cone subtypes. We isolated two kinds of medaka arrestin cDNAs, KfhArr-R and -C, which encode rod and cone arrestin subtypes, respectively (Hisatomi et al., 1997).


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