光受容系の分子進化
−−似て非なるタンパク質サブタイプが担う多様な生理機能−−
Molecular evolution in photo-transduction system
久冨 修、徳永 史生 (1998)
生物物理、38(1), 4-8.
日本語要旨：
一次構造を解析することによって，そこに刻み込まれているタンパク質の歴史を知ることができる．光受容に関与する数種のタンパク質の一次構造を調べることにより，光受容系の保守性と可塑性，情報伝達の効率化のための戦略が見えてくる．タンパク質サブタイプの存在が多様な生理機能を生み出す分子的な基盤となっている．
Abstract：
The molecular evolution of proteins participating in photo-transduction cascades is analyzed and compared. These proteins generally have high membrane affinities, and it seems likely that they have been evolved to use the membrane surface as an efficient field for signal transduction. The divergence between vertebrate rod and cone subtypes of each protein has a relationship with the others, but diversities are found between vertebrate and invertebrate systems. Existence of protein subtypes and their combinations selectively expressed in a cell type may be one of the molecular bases for the diversity of nervous signal transduction.
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